Network pharmacology combining metabolomic analyses was conducted to illustrate the key targets and pathways. Statistical and pathway enrichment analysis was performed in the KEGG pathway database. Potential biomarkers were identified depending on the mass-charge ratio of the selected compound. Multivariate data analyses, including unsupervised principal component analysis (PCA) and supervised orthogonal partial least squares discriminant analysis (OPLS-DA), were performed. Methods: This research explored the mechanism behind the modulatory effects of ZHSE by a strategy of metabolomics and network pharmacology. Based on the traditional prescription Liushen Wan, the pathogenesis and pathology, we developed a new Chinese medicine prescription and made Zhenhuang submicron emulsion (ZHSE) spray, which has an efficacious therapeutic effect for oropharyngeal mucositis. At present, there is no widely available therapeutic for the treatment of oropharyngeal mucositis in clinical practice.

The primary treatment for tumors of the head and neck is radiation therapy, which can induce oropharyngeal mucositis as a side effect. Introduction: Head and neck tumors account for more than 6% of all cancers. *These authors contributed equally to this workĬorrespondence: Guohui Li, Department of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China, Tel +861087788573, Email Wei Chen, 1, * Chunyu Li, 1, * Dujia Jin, 2 Yafei Shi, 1 Mingyu Zhang, 1 Mingming Bo, 1 Di Qian, 1 Mengyang Wang, 1 Guohui Li 1ġDepartment of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China 2Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

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